What do you think is the best cast size for the games you’ve played? What are the factors that go into your answer: genre, play group, gaming system, etc.?
As a general rule, I think the way I look at the ratio is that less roleplaying allows more players, as long as their aren’t so many players that they make combat scenes unwieldy for the players or the GM.
Then there are all the other factors to take into account. Some GMs do better than others with larger groups, regardless of the system. Some players want or need more attention than others. Some systems work better with a certain number of characters.
I think this comes down to another, “It depends.”