There’s an interesting thread over on Story Games (and yes, I do realize how many of my posts are related to Story Games) about playing games at cons with people you know versus playing with people you don’t know.

Personally, when I play prefer a mix, as I’m more at ease socially if there are at least one or two people that I know, but playing with people I’ve never met (or only know from online) means getting to experience new styles of playing and new perspectives on games. When I GM I prefer the balance to lean more toward people I know, as I’m more comfortable running a game if I’m at least somewhat familiar with the players.

The thread’s also got interesting points about getting to know the people you’re playing with, so it’s well worth a read.